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Host cell factor C1 : ウィキペディア英語版 | Host cell factor C1
Host cell factor 1 (HCFC1, HCF1, or HCF-1), also known as VP16-accessory protein,〔(GeneCards entry for HCFC1 ), http://genecards.org〕 is a protein that in humans is encoded by the ''HCFC1'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3054 )〕 == Structure ==
HCF1 is a member of the highly conserved host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear transcription coregulator is proteolytically cleaved at one or more of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains which interact through electrostatic forces.
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